Severe viral infections can lead to dramatically different clinical outcomes among individuals, ranging from asymptomatic infection to life-threatening disease. This project aims to uncover the human genetic and immunological factors that underlie this variability. By integrating human genetics with functional immunology, the student will investigate inborn errors of immunity that impair antiviral defense mechanisms. The project will involve analysis of genomic data from cell lines and/or patients with severe viral infections, followed by experimental validation of candidate genes using molecular and cellular approaches. Particular emphasis will be placed on pathways involved in antiviral immunity, including type I interferon signaling. The student will gain exposure to cutting-edge approaches at the interface of genomics, immunology, and translational medicine.

- Identification of candidate genetic variants associated with severe viral disease - Functional validation of selected variants using cell-based assays - Generation and analysis of experimental data (e.g., gene expression, protein signaling) - A written report summarizing findings and interpretation - Optional contribution to ongoing manuscripts or presentations