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Project Details

Program
Computer Science
Field of Study
Artificial Intelligence
Division
Computer, Electrical and Mathematical Sciences and Engineering
Center Affiliation
Computational Bioscience Research Center

Project Description

Symbolic, logic-based languages are inherently interpretable by humans. Symbols are entities standing for other entities and can be combined to form more complex expressions. Symbol systems are therefore well suited to explain and answer questions of “how” and “why” an intelligent agent (human or artificial) arrived at a decision. Knowledge-based systems based on logic have traditionally been used successfully in question answering (formulated as computing entailments, i.e., statements that must be true if all the axioms are assumed to be true) and can generate novel and “surprising” answers through deductive inference. However, they are not well suited to dealing with incomplete or noisy information or identifying patterns from unstructured data. Machine learning methods, in particular neural networks, can deal with noisy and incomplete data substantially better than symbolic, logic-based methods. However, they operate mainly as black boxes which do not make the logic underlying a decision making process available. Neuro-symbolic methods in Artificial Intelligence aim to combine logic-based AI methods and neural methods to overcome the limitations of both. The aim of the project is the identify, implement, evaluate, and improve neuro-symbolic methods. The baselines and experiments will focus on one of two possible areas of application: biomedical data where a large number of knowledge bases has been developed, or common sense knowledge.

About the Researcher

Robert Hoehndorf
Associate Professor, Computer Science
Computer, Electrical and Mathematical Science and Engineering Division

Affiliations

Education Profile

  • Ph.D., University of Leipzig, 2009
  • M.Sc., University of Leipzig, 2005

Research Interests

a€‹Professor Hoehndorf is interested in artificial intelligence, knowledge representation, biomedical informatics, ontology.

Selected Publications

  • Hoehndorf, R., Queralt-Rosinach, N., a€œData science and symbolic AI: Synergies, challenges and opportunitiesa€. In: Data Science.
  • Boudellioua, I., Mahamad Razali, R. B., Kulmanov, M., Hashish, Y., Bajic, V. B., Goncalves- Serra, E., Schoenmakers, N., Gkoutos, G. V., Schofield, P. N., Hoehndorf, R., a€œSemantic prioritization of novel causative genomic variantsa€. In: PLOS Computational Biology 13.4 (Apr. 2017), pp. 1a-21.
  • Hoehndorf, R., Schofield, P. N., Gkoutos, G. V., a€œAnalysis of the human diseasome using phenotype similarity between common, genetic, and infectious diseasesa€. In: Scientific Reports 5 (June 2015), p. 10888.
  • Robert Hoehndorf, Tanya Hiebert, Nigel W. Hardy, Paul N. Schofield, Georgios V. Gkoutos, and Michel Dumontier. ""Mouse model phenotypes provide information about human drug targets"". In: Bioinformatics (Oct. 2013).
  • Robert Hoehndorf, Paul N. Schofield, and Georgios V. Gkoutos. ""PhenomeNET: a whole-phenome approach to disease gene discovery"". In: Nucleic Acids Research 39.18 (July 2011), e119.

Desired Project Deliverables

Month 1: identification of algorithm, technical presentation Month 2: implementation, baseline experiments Month 3: algorithm evaluation Month 4: analysis, improvement and tuning Month 5: experimental results, theoretical results Month 6: write-up

Recommended Student Background

Semantic Web
machine learning
logic
ontologies

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3-6 months
Internship period
100+
Research Projects
3.5/4
Cumulative GPA
310
Interns a Year